{"id":2855,"date":"2025-06-11T10:09:32","date_gmt":"2025-06-11T09:09:32","guid":{"rendered":"https:\/\/nish.wales\/?p=2855"},"modified":"2026-03-11T08:57:50","modified_gmt":"2026-03-11T08:57:50","slug":"case-study-using-nanotech-to-fight-ovarian-cancer","status":"publish","type":"post","link":"https:\/\/nish.wales\/cy\/2025\/06\/11\/case-study-using-nanotech-to-fight-ovarian-cancer\/","title":{"rendered":"Astudiaeth Achos: Defnyddio Nanodechnoleg i Frwydro Canser yr Ofar\u00efau"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/www.swansea.ac.uk\/staff\/m.hitchings\/\">Dr Matt Hitchings<\/a>, Senior Research Officer at <a href=\"http:\/\/swansea.ac.uk\" target=\"_blank\" rel=\"noreferrer noopener\">Swansea University,<\/a> is leading a multidisciplinary project &#8211; backed by funding from the <a href=\"https:\/\/www.ukri.org\/what-we-do\/browse-our-areas-of-investment-and-support\/mrc-impact-acceleration-accounts-previously-confidence-in-concept\/\">Gyfrif Cyflymu Effaith y Cyngor Ymchwil Feddygol<\/a> &#8211; that may provide a new and highly targeted approach to combating ovarian cancer.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Canser yr ofar\u00efau gradd uchel yw un o'r mathau mwyaf marwol o ganser yr ofar\u00efau, yn aml yn mynd heb ei ganfod nes iddo gyrraedd cam datblygedig. Mae ei natur ymosodol a'i wrthwynebiad i driniaethau traddodiadol yn amlygu'r angen dybryd am strategaethau therapiwtig arloesol. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Wrth wraidd yr ymchwil yw teulu o foleciwlau o'r enw <strong>MicroRNAs (miRNAs)<\/strong>, sef dilyniannau RNA bach, di-godio, sy'n chwarae rhan allweddol wrth reoleiddio mynegiant genynnau. Mewn celloedd iach, mae miRNAs yn helpu i gynnal swyddogaeth arferol trwy droi genynnau \u201cymlaen\u201d neu \u201ci ffwrdd\u201d yn \u00f4l yr angen. Ond mewn celloedd canser, mae mynegiant miRNA yn aml yn cael ei amharu. Gall hyn arwain at gamreoli genynnau allweddol sy'n rheoli twf, rhaniad a goroesiad celloedd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mae rhai miRNAs yn ymddwyn fel <strong>oncogenau<\/strong>, sy'n hyrwyddo twf twimorau, tra bod eraill yn gweithredu fel <strong>atalyddion tiwmorau<\/strong>, sy'n helpu i'w atal. Pan fydd eu mynegiant yn cael ei newid o fewn canser, felly hefyd mae'r llwybrau moleciwlaidd maent yn eu rheoli.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mae'r astudiaeth yn canolbwyntio ar ailgyflwyno miRNAs therapiwtig wedi'i dargedu i adfer cydbwysedd, amharu ar enynnau sy'n hybu canser, ac ail-greu prosesau atal tiwmor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mae'r prosiect yn dwyn ynghyd arbenigedd o eneteg, genomeg, biowybodeg, bioleg foleciwlaidd, a nanodechnoleg. Y nod cyntaf yw datblygu <strong>llif gwaith cyfrifiadurol<\/strong> sy'n defnyddio data moleciwlaidd sydd eisoes yn bodoli i nodi miRNAs a'u targedau genynnau sy'n cael eu camreoli mewn canser yr ofar\u00efau seraidd gradd uchel. Mae'r dull hwn sy'n cael ei yrru gan fiowybodeg yn galluogi'r t\u00eem i adnabod genynnau unigol a <strong>llwybrau<\/strong> cyfan yr amharwyd arnynt a all gael eu dylanwadau gan miRNA unigol.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mae'r dull hwn yn arbennig o bwerus oherwydd <strong>natur pleiotropig<\/strong>miRNAs': gall un miRNA reoleiddio genynnau lluosog, a thrwy estyniad, llwybrau biolegol lluosog. Mae hyn yn agor y posibilrwydd o gyflawni effeithiau therapiwtig ehangach o gymharu \u00e2 thriniaethau un targed traddodiadol.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Yr ail her allweddol y mae'r t\u00eem yn mynd i'r afael \u00e2 hi yw <strong>cyflawni<\/strong>. Mae miRNAs sy'n arnofio'n rhydd yn cael eu diraddio'n gyflym yn y corff ac yn brwydro i dreiddio meinweoedd. I oresgyn hyn, mae t\u00eem Dr Hitchings wedi defnyddio technoleg nano-gapsiwleiddio uwch. Mae'r dull hwn yn cynnwys ymgorffori miRNAs o fewn nanoronynnau, gan eu hamddiffyn rhag diraddio a gwella eu gallu i gyrraedd a threiddio celloedd tiwmor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mae canlyniadau cychwynnol y labordy yn addawol iawn. Mae'r t\u00eem wedi nodi sawl ymgeisydd miRNA newydd nad ydynt wedi'u harchwilio o'r blaen ar gyfer defnydd therapiwtig, sy'n dangos gweithgaredd cryf o'i gymhwyso i linellau celloedd canser yr ofar\u00efau. Mae'r miRNAs sydd wedi'u crynhoi yn mynd i mewn i'r celloedd canser yn fwy effeithlon ac yn arwain at lefelau sylweddol uwch o farwolaethau celloedd canser o gymharu \u00e2 ffurf heb eu diogelu.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This project represents a bold and innovative shift in cancer treatment &#8211; moving from broad-spectrum chemotherapy to precision molecular reprogramming. By combining cutting-edge bioinformatics with advanced nanotechnology, the team are creating tools that could transform how we treat ovarian cancer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Y nod hirdymor yw datblygu ffordd i ddarparu therap\u00efau wedi\u2019u targedu ac sy\u2019n lleihau sgil-effeithiau ar gyfer cleifion risg uchel. Wrth i'r ymchwil fynd yn ei flaen, efallai y bydd hefyd yn cael ei addasu i ganserau eraill sy'n anodd eu trin, gan ei wneud yn gam gwerthfawr ymlaen mewn meddygaeth bersonol.<\/p>\n\n\n\n<figure class=\"wp-block-video aligncenter wp-block-embed is-type-video is-provider-videopress\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"VideoPress Video Player\" aria-label='VideoPress Video Player' width='500' height='281' src='https:\/\/videopress.com\/embed\/SPNqForA?cover=1&amp;posterUrl=https%3A%2F%2Fnish.wales%2Fwp-content%2Fuploads%2F2025%2F04%2Fmatt-hitchings-mrc-iaa-film-_mov_avc_240p.original.jpg&amp;preloadContent=metadata&amp;useAverageColor=1&amp;hd=0' frameborder='0' allowfullscreen data-resize-to-parent=\"true\" allow='clipboard-write'><\/iframe><script src='https:\/\/v0.wordpress.com\/js\/next\/videopress-iframe.js?m=1770107250'><\/script>\n<\/div><figcaption>Dr Matt Hitchings o Brifysgol Abertawe<\/figcaption><\/figure>","protected":false},"excerpt":{"rendered":"<p>Dr Matt Hitchings, Senior Research Officer at Swansea University, is leading a multidisciplinary project &#8211; backed by funding from the Medical Research Council\u2019s Impact Acceleration Account &#8211; that may provide a new and highly targeted approach to combating ovarian cancer. High-grade serous ovarian cancer is one of the deadliest forms of ovarian cancer, often going [&hellip;]<\/p>\n","protected":false},"author":190346150,"featured_media":2859,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1367],"tags":[1375,1369,1370],"class_list":["post-2855","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-case-study","tag-health","tag-innovation","tag-technology"],"jetpack_publicize_connections":[],"jetpack_likes_enabled":false,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pfwlnl-K3","jetpack-related-posts":[{"id":2827,"url":"https:\/\/nish.wales\/cy\/2025\/04\/23\/case-study-new-funding-to-tackle-ovarian-cancer-resistance\/","url_meta":{"origin":2855,"position":0},"title":"Astudiaeth Achos: Cyllid Newydd i Ddatrys Ymwrthedd i Ganser yr Ofar\u00efau","author":"meganchick1","date":"23rd Ebrill 2025","format":false,"excerpt":"Despite decades of research and medical advances, treatment options for high-grade serous ovarian cancer - the most aggressive and common form of the illness - remain largely unchanged since the 1950s. However, new research led by Associate Professor James Cronin at Swansea University is aiming to change this with funding\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2822,"url":"https:\/\/nish.wales\/cy\/2025\/04\/23\/case-study-diagnosing-lung-cancer-using-non-invasive-blood-testing\/","url_meta":{"origin":2855,"position":1},"title":"Astudiaeth Achos: Canfod Canser yr Ysgyfaint gan Ddefnyddio Profion Gwaed Anfewnwthiol","author":"meganchick1","date":"23rd Ebrill 2025","format":false,"excerpt":"In a pioneering research project, Network members Cansense, Swansea University, and Swansea Bay University Health Board have received further funding to develop a breakthrough approach in detecting lung cancer earlier with a simple blood test. Lung cancer is one of the UK\u2019s deadliest cancers, with late diagnoses contributing to poor\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":1021,"url":"https:\/\/nish.wales\/cy\/2024\/04\/30\/case-study-revolutionising-cancer-detection-with-new-non-invasive-test\/","url_meta":{"origin":2855,"position":2},"title":"Astudiaeth Achos: Chwyldroi Canfod Canser gyda Phrawf Anfewnwthiol Newydd","author":"meganchick1","date":"30th Ebrill 2024","format":false,"excerpt":"CanSense is a Swansea University spinout company with big aspirations; to transform early-stage cancer detection. Prioritising accuracy, inclusion, and scalability, the company\u2019s optimised test targets the prevalent issue of bowel cancer. By employing Raman Spectroscopy on blood samples and leveraging AI analysis, CanSense identifies early-stage bowel cancer and pre-cancerous polyps.\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2837,"url":"https:\/\/nish.wales\/cy\/2025\/05\/07\/case-study-a-blood-test-to-detect-aggressive-prostate-cancer-earlier\/","url_meta":{"origin":2855,"position":3},"title":"Astudiaeth Achos: Prawf Gwaed i Ganfod Canser y Prostad Ymosodol yn Gynharach","author":"meganchick1","date":"7th Mai 2025","format":false,"excerpt":"Dr Jason Webber and his team at Swansea University are tackling early intervention for aggressive prostate cancer, developing a simple and highly promising blood test to identify men with high-risk prostate cancer earlier and more accurately. 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While many modern cancer drugs are highly potent, they can be unstable in the body, accumulate in healthy tissues, or cause significant side effects, limiting their effectiveness. 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