{"id":2865,"date":"2025-06-25T13:41:29","date_gmt":"2025-06-25T12:41:29","guid":{"rendered":"https:\/\/nish.wales\/?p=2865"},"modified":"2026-03-11T08:50:48","modified_gmt":"2026-03-11T08:50:48","slug":"case-study-tumour-targeting-bacteria-for-safer-smarter-cancer-treatment","status":"publish","type":"post","link":"https:\/\/nish.wales\/cy\/2025\/06\/25\/case-study-tumour-targeting-bacteria-for-safer-smarter-cancer-treatment\/","title":{"rendered":"Astudiaeth Achos: Defnyddio Bacteria sy'n Targedu Tiwmor ar gyfer Triniaeth Canser Ddiogelach a Doethach"},"content":{"rendered":"<p class=\"wp-block-paragraph translation-block\"><strong>Mae'r <a href=\"https:\/\/www.swansea.ac.uk\/staff\/p.j.dyson\/\" target=\"_blank\" rel=\"noreferrer noopener\">Athro Paul Dyson<\/a> a'i d\u00eem ym <a href=\"http:\/\/swansea.ac.uk\" target=\"_blank\" rel=\"noreferrer noopener\">Mhrifysgol Abertawe<\/a> yn gweithio ar ddulliau i ddarparu triniaeth yn ddetholus i diwmorau, gan osgoi gweddill y corff, diolch i gymorth ariannol gan <a href=\"https:\/\/www.ukri.org\/what-we-do\/browse-our-areas-of-investment-and-support\/mrc-impact-acceleration-accounts-previously-confidence-in-concept\/\" target=\"_blank\" rel=\"noreferrer noopener\"> Gyfrif Cyflymu Effaith y Cyngor Ymchwil Feddygol<\/a>.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mae triniaethau canser confensiynol fel cemotherapi a radiotherapi, er eu bod yn effeithiol, yn aml yn cyd-fynd \u00e2 sgil-effeithiau difrifol oherwydd eu diffyg penodoldeb - gan niweidio nid yn unig tiwmorau ond meinwe iach hefyd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mae'r ymchwil arloesol hon yn canolbwyntio ar genhedlaeth newydd o therap\u00efau canser biolegol sy'n harneisio priodweddau naturiol bacteria. Mae rhai mathau o facteria yn ffynnu o dan amodau unigryw tiwmor, megis ocsigen isel a pH asidig - anaml y ceir cyflyrau mewn meinwe iach. Mae hyn yn eu gwneud yn gyfryngau delfrydol ar gyfer dosbarthu cyfryngau therapiwtig yn uniongyrchol i'r tiwmor, gan adael gweddill y corff heb ei gyffwrdd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Yng nghyfnodau cynharach yr ymchwil, canolbwyntiodd y t\u00eem ar ddefnyddio'r bacteria hyn i atal twf tiwmorau, gan ddarparu llwythi therapiwtig sy'n atal datblygiad y canser. Nawr, mae eu hymdrechion wedi esblygu i ddull gweithredu deuol. Mae'r bacteria hyn yn lladd celloedd tiwmor yn uniongyrchol ac yn helpu i ysgogi system imiwnedd y corff, gan ei ddysgu i adnabod ac ymladd y canser yn fwy effeithiol.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gallai'r effaith gyfunol hon o ladd celloedd canser ac ail-actifadu'r system imiwnedd gynnig manteision hirdymor y tu hwnt i'r hyn sy'n bosibl gyda thriniaethau cyfredol.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Yn wahanol i gemotherapi neu ymbelydredd, na all wahaniaethu rhwng meinwe iach a chanseraidd, mae'r therapi bacteriol hwn yn benodol iawn. Mae'r bacteria'n tueddu'n naturiol i safleoedd tiwmor, gan leihau'r risg o niwed i organau a meinweoedd iach yn sylweddol. Mae hyn yn golygu y gallai cleifion gael eu harbed rhag llawer o'r sg\u00eel-effeithiau niweidiol sy'n gysylltiedig yn gyffredin \u00e2 thriniaethau canser traddodiadol, fel blinder, cyfog, ac atal imiwnedd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mae'r ymchwil eisoes yn cynhyrchu canlyniadau addawol mewn modelau anifeiliaid arbrofol. Mae anifeiliaid sy'n dwyn tiwmorau sy'n cael eu trin \u00e2'r therapi yn byw'n sylweddol hirach, ac yn bwysig, nid yw'r driniaeth wedi dangos unrhyw sg\u00eel-effeithiau niweidiol hyd yn hyn. Mae'r canfyddiadau hyn yn gosod y sylfaen ar gyfer cymwysiadau clinigol yn y dyfodol.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mae'r t\u00eem bellach yn gweithio ar optimeiddio'r therapi ac yn archwilio ffyrdd o ehangu ar gyfer treialon dynol posibl. Os bydd yn llwyddiannus, gallai'r dull hwn chwyldroi sut rydym yn trin canser, gan gynnig opsiwn mwy diogel, mwy manwl gywir a mwy effeithiol i gleifion.<\/p>\n\n\n\n<figure class=\"wp-block-video aligncenter wp-block-embed is-type-video is-provider-videopress\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"VideoPress Video Player\" aria-label='VideoPress Video Player' width='500' height='281' src='https:\/\/videopress.com\/embed\/khm47ykK?cover=1&amp;posterUrl=https%3A%2F%2Fnish.wales%2Fwp-content%2Fuploads%2F2025%2F04%2Fpaul-dyson-mrc-iaa-film_mp4_avc_240p.original.jpg&amp;preloadContent=metadata&amp;useAverageColor=1&amp;hd=0' frameborder='0' allowfullscreen data-resize-to-parent=\"true\" allow='clipboard-write'><\/iframe><script src='https:\/\/v0.wordpress.com\/js\/next\/videopress-iframe.js?m=1770107250'><\/script>\n<\/div><figcaption>Yr Athro Paul Dyson a Severina Peneva o Brifysgol Abertawe<\/figcaption><\/figure>","protected":false},"excerpt":{"rendered":"<p>Professor Paul Dyson and his team at Swansea University are working on methods to selectively deliver treatment only to tumours, avoiding the rest of the body, thanks to funding from the Medical Research Council\u2019s Impact Acceleration Account. Conventional cancer treatments like chemotherapy and radiotherapy, while effective, are often accompanied by severe side effects due to [&hellip;]<\/p>\n","protected":false},"author":190346150,"featured_media":2883,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1367],"tags":[1375,1370],"class_list":["post-2865","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-case-study","tag-health","tag-technology"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-6.png?fit=1200%2C628&ssl=1","jetpack_likes_enabled":false,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pfwlnl-Kd","jetpack-related-posts":[{"id":2855,"url":"https:\/\/nish.wales\/cy\/2025\/06\/11\/case-study-using-nanotech-to-fight-ovarian-cancer\/","url_meta":{"origin":2865,"position":0},"title":"Astudiaeth Achos: Defnyddio Nanodechnoleg i Frwydro Canser yr Ofar\u00efau","author":"meganchick1","date":"11th Mehefin 2025","format":false,"excerpt":"Dr Matt Hitchings, Senior Research Officer at Swansea University, is leading a multidisciplinary project - backed by funding from the Medical Research Council\u2019s Impact Acceleration Account - that may provide a new and highly targeted approach to combating ovarian cancer. High-grade serous ovarian cancer is one of the deadliest forms\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-5.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-5.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-5.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-5.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-5.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2827,"url":"https:\/\/nish.wales\/cy\/2025\/04\/23\/case-study-new-funding-to-tackle-ovarian-cancer-resistance\/","url_meta":{"origin":2865,"position":1},"title":"Astudiaeth Achos: Cyllid Newydd i Ddatrys Ymwrthedd i Ganser yr Ofar\u00efau","author":"meganchick1","date":"23rd Ebrill 2025","format":false,"excerpt":"Despite decades of research and medical advances, treatment options for high-grade serous ovarian cancer - the most aggressive and common form of the illness - remain largely unchanged since the 1950s. However, new research led by Associate Professor James Cronin at Swansea University is aiming to change this with funding\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2837,"url":"https:\/\/nish.wales\/cy\/2025\/05\/07\/case-study-a-blood-test-to-detect-aggressive-prostate-cancer-earlier\/","url_meta":{"origin":2865,"position":2},"title":"Astudiaeth Achos: Prawf Gwaed i Ganfod Canser y Prostad Ymosodol yn Gynharach","author":"meganchick1","date":"7th Mai 2025","format":false,"excerpt":"Dr Jason Webber and his team at Swansea University are tackling early intervention for aggressive prostate cancer, developing a simple and highly promising blood test to identify men with high-risk prostate cancer earlier and more accurately. Prostate cancer is the most commonly diagnosed cancer among men in the UK, with\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2-1.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2-1.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2-1.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2-1.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2-1.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2822,"url":"https:\/\/nish.wales\/cy\/2025\/04\/23\/case-study-diagnosing-lung-cancer-using-non-invasive-blood-testing\/","url_meta":{"origin":2865,"position":3},"title":"Astudiaeth Achos: Canfod Canser yr Ysgyfaint gan Ddefnyddio Profion Gwaed Anfewnwthiol","author":"meganchick1","date":"23rd Ebrill 2025","format":false,"excerpt":"In a pioneering research project, Network members Cansense, Swansea University, and Swansea Bay University Health Board have received further funding to develop a breakthrough approach in detecting lung cancer earlier with a simple blood test. Lung cancer is one of the UK\u2019s deadliest cancers, with late diagnoses contributing to poor\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":1021,"url":"https:\/\/nish.wales\/cy\/2024\/04\/30\/case-study-revolutionising-cancer-detection-with-new-non-invasive-test\/","url_meta":{"origin":2865,"position":4},"title":"Astudiaeth Achos: Chwyldroi Canfod Canser gyda Phrawf Anfewnwthiol Newydd","author":"meganchick1","date":"30th Ebrill 2024","format":false,"excerpt":"CanSense is a Swansea University spinout company with big aspirations; to transform early-stage cancer detection. Prioritising accuracy, inclusion, and scalability, the company\u2019s optimised test targets the prevalent issue of bowel cancer. By employing Raman Spectroscopy on blood samples and leveraging AI analysis, CanSense identifies early-stage bowel cancer and pre-cancerous polyps.\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":4173,"url":"https:\/\/nish.wales\/cy\/2025\/11\/06\/case-study-early-intervention-of-hepatitis-c-treatment-within-marginalised-patient-groups\/","url_meta":{"origin":2865,"position":5},"title":"Astudiaeth Achos: Ymyrraeth Gynnar Triniaeth Hepatitis C gyda Grwpiau Cleifion Ymylol","author":"meganchick1","date":"6th Tachwedd 2025","format":false,"excerpt":"Hepatitis C is an infectious virus which particularly affects marginalised and vulnerable populations such as homeless people. It may have become more widespread during COVID-19. Untreated, hepatitis C can lead to cirrhosis, liver failure, and liver cancer. Testing and early intervention of this disease can help to reduce the occurrence\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-6.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-6.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-6.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-6.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-6.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/posts\/2865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/users\/190346150"}],"replies":[{"embeddable":true,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/comments?post=2865"}],"version-history":[{"count":9,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/posts\/2865\/revisions"}],"predecessor-version":[{"id":4130,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/posts\/2865\/revisions\/4130"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/media\/2883"}],"wp:attachment":[{"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/media?parent=2865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/categories?post=2865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/tags?post=2865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}