{"id":5222,"date":"2026-09-03T10:47:28","date_gmt":"2026-09-03T09:47:28","guid":{"rendered":"https:\/\/nish.wales\/?p=5222"},"modified":"2026-09-03T10:47:30","modified_gmt":"2026-09-03T09:47:30","slug":"advancing-targeted-drug-delivery-for-pancreatic-cancer","status":"publish","type":"post","link":"https:\/\/nish.wales\/cy\/2026\/09\/03\/advancing-targeted-drug-delivery-for-pancreatic-cancer\/","title":{"rendered":"Datblygu Cyflenwi Cyffuriau wedi'i Dargedu ar gyfer Canser y Pancreas"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Mae trin canser y pancreas yn parhau i fod yn un o'r heriau mwyaf mewn oncoleg. Er bod llawer o gyffuriau canser modern yn gryf iawn, gallant fod yn ansefydlog yn y corff, cronni mewn meinweoedd iach, neu achosi sg\u00eel-effeithiau sylweddol, gan gyfyngu ar eu heffeithiolrwydd. Mae ymchwilwyr ym Mhrifysgol Abertawe yn gweithio i fynd i'r afael \u00e2'r her hon trwy blatfform cyflenwi cyffuriau arloesol a gynlluniwyd i helpu triniaethau i gyrraedd tiwmorau yn fwy effeithiol.&nbsp;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Wedi'i arwain gan <a href=\"https:\/\/www.swansea.ac.uk\/staff\/l.francis\/\"><strong>Yr Athro Lewis Francis<\/strong><\/a>, Arweinydd Academaidd a Chyd-Ddyfeisiwr Rhaglen Nanoronynnau MRC Abertawe, ynghyd \u00e2 <strong><a href=\"https:\/\/www.linkedin.com\/in\/kadie-edwards\/\">Dr Kadie Edwards<\/a><\/strong>, Swyddog Ymchwil, Datblygu ac Arloesi a Chyd-Ddyfeisiwr, mae'r t\u00eem wedi datblygu&nbsp;<strong>Nanoport<\/strong>, platfform perchnogol o nanoronynnau polymerig sy'n gallu cario ystod eang o asiantau therapiwtig. Mae'r dechnoleg wedi'i chynllunio i amddiffyn cyffuriau wrth iddynt gael eu danfon, gwella targedu i safleoedd clefydau, a lleihau gwenwyndra oddi ar y targed.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gyda chefnogaeth gan gyllid <a href=\"https:\/\/www.ukri.org\/what-we-do\/browse-our-areas-of-investment-and-support\/mrc-impact-acceleration-accounts-previously-confidence-in-concept\/\">MRC IAA<\/a> , mae'r ymchwilwyr nawr yn datblygu'r genhedlaeth nesaf o fformwleiddiadau Nanoport ar gyfer canser y pancreas. Mae'r prosiect yn canolbwyntio ar oresgyn un o rwystrau mwyaf arwyddocaol yr afiechyd: sicrhau bod meddyginiaethau yn callu treiddio a chyrraedd y tiwmor yn effeithiol.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mae'r t\u00eem yn addasu Nanoport i ddarparu therap\u00efau canser newydd addawol, gan gynnwys atalyddion KRAS, tra'n datblygu eiddo deallusol newydd o amgylch y fformwleiddiadau hyn ar yr un pryd. Ochr yn ochr ag optimeiddio a phrofi perfformiad, mae'r prosiect yn cynhyrchu'r dystiolaeth sydd ei hangen i gefnogi datblygiad clinigol yn y dyfodol a chyfleoedd ariannu ar raddfa fwy.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Y nod yn y pen draw yw nodi prif ymgeisydd triniaeth a all symud ymlaen tuag at gymhwysiad clinigol, gan osod y sylfaen ar gyfer therap\u00efau mwy effeithiol a thargedig ar gyfer cleifion canser y pancreas.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Mae <strong>Dr Kadie Edwards<\/strong> yn egluro:<em>\u201cNod ein technoleg Nanoport patent yw datrys hyn trwy ddarparu triniaethau'n uniongyrchol i'r tiwmor.\u201d<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The\u00a0Nanoport platform has the potential to improve the delivery and effectiveness of next-generation cancer therapies, supporting the development of targeted treatments for one of the most difficult cancers to treat while creating valuable new intellectual property and future commercial opportunities.<\/p>\n\n\n\n\t\t<figure class=\"wp-block-jetpack-videopress jetpack-videopress-player aligncenter\" style=\"\" >\n\t\t\t<div class=\"jetpack-videopress-player__wrapper\"> <iframe title=\"VideoPress Video Player\" aria-label=\"VideoPress Video Player\" width=\"500\" height=\"281\" src=\"https:\/\/videopress.com\/embed\/YF1nXWrE?cover=1&amp;autoPlay=0&amp;controls=1&amp;loop=0&amp;muted=0&amp;persistVolume=1&amp;playsinline=0&amp;preloadContent=metadata&amp;useAverageColor=1&amp;hd=0\" frameborder=\"0\" allowfullscreen data-resize-to-parent=\"true\" allow=\"clipboard-write; presentation\"><\/iframe><script src='https:\/\/v0.wordpress.com\/js\/next\/videopress-iframe.js?m=1770107250'><\/script><\/div>\n\t\t\t\n\t\t\t\n\t\t<\/figure>","protected":false},"excerpt":{"rendered":"<p>Treating pancreatic cancer remains one of the biggest challenges in oncology. While many modern cancer drugs are highly potent, they can be unstable in the body, accumulate in healthy tissues, or cause significant side effects, limiting their effectiveness. Researchers at Swansea University are working to address this challenge through an innovative drug delivery platform designed [&hellip;]<\/p>\n","protected":false},"author":190346150,"featured_media":5229,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1367,1366],"tags":[1375,1368,1370],"class_list":["post-5222","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-case-study","category-news","tag-health","tag-research","tag-technology"],"jetpack_publicize_connections":[],"jetpack_likes_enabled":false,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pfwlnl-1me","jetpack-related-posts":[{"id":2855,"url":"https:\/\/nish.wales\/cy\/2025\/06\/11\/case-study-using-nanotech-to-fight-ovarian-cancer\/","url_meta":{"origin":5222,"position":0},"title":"Astudiaeth Achos: Defnyddio Nanodechnoleg i Frwydro Canser yr Ofar\u00efau","author":"meganchick1","date":"11th Mehefin 2025","format":false,"excerpt":"Dr Matt Hitchings, Senior Research Officer at Swansea University, is leading a multidisciplinary project - backed by funding from the Medical Research Council\u2019s Impact Acceleration Account - that may provide a new and highly targeted approach to combating ovarian cancer. High-grade serous ovarian cancer is one of the deadliest forms\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-5.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-5.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-5.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-5.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-5.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2827,"url":"https:\/\/nish.wales\/cy\/2025\/04\/23\/case-study-new-funding-to-tackle-ovarian-cancer-resistance\/","url_meta":{"origin":5222,"position":1},"title":"Astudiaeth Achos: Cyllid Newydd i Ddatrys Ymwrthedd i Ganser yr Ofar\u00efau","author":"meganchick1","date":"23rd Ebrill 2025","format":false,"excerpt":"Despite decades of research and medical advances, treatment options for high-grade serous ovarian cancer - the most aggressive and common form of the illness - remain largely unchanged since the 1950s. However, new research led by Associate Professor James Cronin at Swansea University is aiming to change this with funding\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2822,"url":"https:\/\/nish.wales\/cy\/2025\/04\/23\/case-study-diagnosing-lung-cancer-using-non-invasive-blood-testing\/","url_meta":{"origin":5222,"position":2},"title":"Astudiaeth Achos: Canfod Canser yr Ysgyfaint gan Ddefnyddio Profion Gwaed Anfewnwthiol","author":"meganchick1","date":"23rd Ebrill 2025","format":false,"excerpt":"In a pioneering research project, Network members Cansense, Swansea University, and Swansea Bay University Health Board have received further funding to develop a breakthrough approach in detecting lung cancer earlier with a simple blood test. Lung cancer is one of the UK\u2019s deadliest cancers, with late diagnoses contributing to poor\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2921,"url":"https:\/\/nish.wales\/cy\/2025\/05\/08\/health-needs-assessment-transforming-care-across-south-west-wales\/","url_meta":{"origin":5222,"position":3},"title":"Asesiad Anghenion Iechyd yn Trawsnewid Gofal yn Ne-Orllewin Cymru","author":"meganchick1","date":"8th Mai 2025","format":false,"excerpt":"The comprehensive Health Needs Assessment (HNA) that we recently worked on with ARCH, Swansea Bay University Health Board and Hywel Dda University Health Board, has been pivotal in identifying key health challenges within the region, informing subsequent activities, such as our Health Insights Workshops and the ARCH Innovation Forum. We\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/05\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/05\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/05\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/05\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/05\/Wordpress-2.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":1021,"url":"https:\/\/nish.wales\/cy\/2024\/04\/30\/case-study-revolutionising-cancer-detection-with-new-non-invasive-test\/","url_meta":{"origin":5222,"position":4},"title":"Astudiaeth Achos: Chwyldroi Canfod Canser gyda Phrawf Anfewnwthiol Newydd","author":"meganchick1","date":"30th Ebrill 2024","format":false,"excerpt":"CanSense is a Swansea University spinout company with big aspirations; to transform early-stage cancer detection. Prioritising accuracy, inclusion, and scalability, the company\u2019s optimised test targets the prevalent issue of bowel cancer. By employing Raman Spectroscopy on blood samples and leveraging AI analysis, CanSense identifies early-stage bowel cancer and pre-cancerous polyps.\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/cy\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Wordpress-Featured-Image-1.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":518,"url":"https:\/\/nish.wales\/cy\/2023\/11\/21\/swansea-university-to-develop-world-first-research-and-innovation-living-lab\/","url_meta":{"origin":5222,"position":5},"title":"PRIFYSGOL ABERTAWE I DDATBLYGU'R LABORDY YMCHWIL AC ARLOESI BYW CYNTAF YN Y BYD","author":"meganchick1","date":"21st Tachwedd 2023","format":false,"excerpt":"Swansea University is set to develop a world-first research and innovation environment that harnesses 5G infrastructure to improve population health and wellbeing, with the award of a \u00a32.58M project that will create a \u201cliving laboratory\u201d in the Swansea Bay City Region. This \u201cliving lab\u201d, will support innovation of original device\u2026","rel":"","context":"In &quot;News&quot;","block_context":{"text":"News","link":"https:\/\/nish.wales\/cy\/category\/news\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Hilary-Clinton-Vodafone.webp?fit=1200%2C567&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Hilary-Clinton-Vodafone.webp?fit=1200%2C567&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Hilary-Clinton-Vodafone.webp?fit=1200%2C567&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Hilary-Clinton-Vodafone.webp?fit=1200%2C567&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/04\/Hilary-Clinton-Vodafone.webp?fit=1200%2C567&ssl=1&resize=1050%2C600 3x"},"classes":[]}],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/09\/Wordpress.png?fit=1200%2C628&ssl=1","_links":{"self":[{"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/posts\/5222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/users\/190346150"}],"replies":[{"embeddable":true,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/comments?post=5222"}],"version-history":[{"count":4,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/posts\/5222\/revisions"}],"predecessor-version":[{"id":5233,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/posts\/5222\/revisions\/5233"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/media\/5229"}],"wp:attachment":[{"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/media?parent=5222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/categories?post=5222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nish.wales\/cy\/wp-json\/wp\/v2\/tags?post=5222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}