{"id":4186,"date":"2024-03-12T11:39:00","date_gmt":"2024-03-12T11:39:00","guid":{"rendered":"https:\/\/nish.wales\/?p=4186"},"modified":"2026-03-12T11:48:15","modified_gmt":"2026-03-12T11:48:15","slug":"case-study-a-review-of-capsule-formulations-and-extended-release-pepsin-mechanisms","status":"publish","type":"post","link":"https:\/\/nish.wales\/en\/2024\/03\/12\/case-study-a-review-of-capsule-formulations-and-extended-release-pepsin-mechanisms\/","title":{"rendered":"Case Study: A review of capsule formulations and extended-release pepsin mechanisms"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Bridgend-based <a href=\"http:\/\/www.argip.co.uk\/\">ARGiP Technologies Ltd<\/a> manufacture technologies and raw materials for diagnostic, cosmetic, and food complements use.\u00a0<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ARGiP contacted Swansea University\u2019s <a href=\"https:\/\/www.swansea.ac.uk\/medicine\/enterprise-and-innovation\/business-support-projects\/accelerate-healthcare-technology-centre\/\">Healthcare Technology Centre<\/a> (HTC) seeking support via the Accelerate Programme to consolidate the understanding of pepsin biology to aid in the development of a refined pepsin supplement for the company.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pepsin is a stomach enzyme that breaks down food. It is produced in the gastric chief cells of the stomach lining and is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Soft-shell and hard-shell capsules both play a significant role in the oral delivery of drugs and supplements. However, the research surrounding oral supplement delivery is lacking and needs to be addressed.&nbsp; HTC was challenged to provide a clear understanding of the encapsulation process and provide in-depth knowledge of the different extended-release mechanisms used oral dosage systems, relating these findings to pepsin encapsulation.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The literature surrounding the production and filling of capsule dosage forms go beyond the scope of this review. However, HTC has identified the key concepts within the production and filling process involving pepsin. This collaboration has stimulated the company\u2019s research and understanding of pepsin biology, capsule technology, and formulations.&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This research will play a key role in the development of ARGiP\u2019s refined pepsin supplement which could lead to company growth and more jobs created in Wales.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bridgend-based ARGiP Technologies Ltd manufacture technologies and raw materials for diagnostic, cosmetic, and food complements use.\u00a0 ARGiP contacted Swansea University\u2019s Healthcare Technology Centre (HTC) seeking support via the Accelerate Programme to consolidate the understanding of pepsin biology to aid in the development of a refined pepsin supplement for the company. Pepsin is a stomach enzyme [&hellip;]<\/p>\n","protected":false},"author":190346150,"featured_media":4187,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1367],"tags":[1375,1368],"class_list":["post-4186","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-case-study","tag-health","tag-research"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-9.png?fit=1200%2C628&ssl=1","jetpack_likes_enabled":false,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pfwlnl-15w","jetpack-related-posts":[{"id":2827,"url":"https:\/\/nish.wales\/en\/2025\/04\/23\/case-study-new-funding-to-tackle-ovarian-cancer-resistance\/","url_meta":{"origin":4186,"position":0},"title":"Case Study: New Funding to Tackle Ovarian Cancer Resistance","author":"meganchick1","date":"23rd April 2025","format":false,"excerpt":"Despite decades of research and medical advances, treatment options for high-grade serous ovarian cancer - the most aggressive and common form of the illness - remain largely unchanged since the 1950s. However, new research led by Associate Professor James Cronin at Swansea University is aiming to change this with funding\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/en\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/04\/Wordpress-1-2.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":4215,"url":"https:\/\/nish.wales\/en\/2024\/03\/13\/case-study-combining-biology-and-software-to-help-people-live-better\/","url_meta":{"origin":4186,"position":1},"title":"Case Study: Combining biology and software to help people live better","author":"meganchick1","date":"13th March 2024","format":false,"excerpt":"Glucose Republic\u00a0is combining biology and software to help people eat and live better through the means of\u00a0tracking and monitoring how blood glucose responds to different nutrition in real-time\u00a0circumstances. Each of us has a unique food fingerprint which we can access via our own glucose response to food and exercise\u00a0and this\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/en\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-4-2.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-4-2.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-4-2.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-4-2.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-4-2.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2846,"url":"https:\/\/nish.wales\/en\/2025\/05\/21\/case-study-harnessing-gut-brain-signalling-to-boost-cognitive-health-in-parkinsons-dementia\/","url_meta":{"origin":4186,"position":2},"title":"Case Study: Harnessing Gut-Brain Signalling to Boost Cognitive Health in Parkinson\u2019s Dementia","author":"meganchick1","date":"21st May 2025","format":false,"excerpt":"Groundbreaking research at Swansea University is exploring the vital connection between gut hormones and brain function research that could pave the way for new treatments for cognitive decline in neurodegenerative diseases. 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It focuses on advancing healthcare technologies through rigorous clinical trials, real-world evaluations, and expert regulatory guidance. The institute serves a vital role in bringing cutting-edge medical technologies from concept to implementation\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/en\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/10\/Wordpress-3.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/10\/Wordpress-3.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/10\/Wordpress-3.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/10\/Wordpress-3.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2024\/10\/Wordpress-3.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":491,"url":"https:\/\/nish.wales\/en\/2024\/04\/10\/case-study-novel-technology-for-low-cost-pesticide-development\/","url_meta":{"origin":4186,"position":5},"title":"Case Study: Novel Technology created to develop low-cost pesticides","author":"meganchick1","date":"10th April 2024","format":false,"excerpt":"In the ever-evolving world, the art of forging genuine connections remains timeless. 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