{"id":4224,"date":"2024-03-13T13:43:00","date_gmt":"2024-03-13T13:43:00","guid":{"rendered":"https:\/\/nish.wales\/?p=4224"},"modified":"2026-03-13T13:47:00","modified_gmt":"2026-03-13T13:47:00","slug":"case-study-silicon-coated-steel-microneedle-penetration-and-drug-delivery","status":"publish","type":"post","link":"https:\/\/nish.wales\/en\/2024\/03\/13\/case-study-silicon-coated-steel-microneedle-penetration-and-drug-delivery\/","title":{"rendered":"Case Study: Silicon coated steel microneedle penetration and drug delivery"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Xobaderm is an antiaging focused company which integrates the use of microneedles to deliver compounds to the skin which aims to not just cover up the external signs of aging skin,but aiming to instead slow cellular aging.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Xobaderm have developed Xobaflex\u2122 a patented a unique microneedling system following 10 years of research and refinement. Xobaflex\u2122 combines the benefits of steel with the user-friendly feel of silicone rubber.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Xobaderm\u2019s bold vision is to bring advances in the fundamental biology of ageing to skincare. Existing \u201canti-ageing\u201d treatments have no effect on the rate or progress of ageing. Xobaderm has negotiated an exclusive deal with a major US corporation for a molecule name NR, that has been shown to shift the dial on the fundamentals on cellular aging.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, this molecule is problematic for use in skin care because it cannot pass through the intact stratum corneum and is unstable in traditional forms like creams. Xobaderm have overcome these two problems by using their microneedle system and a sealed wipe that is rehydrated at the point of use.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The collaboration between Swansea University&#8217;s <a href=\"https:\/\/www.swansea.ac.uk\/medicine\/enterprise-and-innovation\/business-support-projects\/accelerate-healthcare-technology-centre\/\">Healthcare Technology Centre<\/a> and Xobaderm investigated the usability\/customer acceptance of their microneedle system and \u201cclinical\u201d effect of NR relating to the biochemical changes of cellular ageing in skin cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xobaderm is an antiaging focused company which integrates the use of microneedles to deliver compounds to the skin which aims to not just cover up the external signs of aging skin,but aiming to instead slow cellular aging. Xobaderm have developed Xobaflex\u2122 a patented a unique microneedling system following 10 years of research and refinement. Xobaflex\u2122 [&hellip;]<\/p>\n","protected":false},"author":190346150,"featured_media":4226,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1367],"tags":[1375,1368,1370],"class_list":["post-4224","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-case-study","tag-health","tag-research","tag-technology"],"jetpack_publicize_connections":[],"jetpack_likes_enabled":false,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pfwlnl-168","jetpack-related-posts":[{"id":4242,"url":"https:\/\/nish.wales\/en\/2024\/03\/16\/case-study-swansea-university-partnership-develops-new-micro-needle-applicator\/","url_meta":{"origin":4224,"position":0},"title":"Case Study: Swansea University partnership develops new micro needle applicator","author":"meganchick1","date":"16th March 2024","format":false,"excerpt":"Innoture holds worldwide patents in the manufacture of microneedle patches, the only company that has increased the mass production of flexible base\u00a0patches worldwide. Innoture Ltd\u00a0customise\u00a0the design and manufacture\u00a0a microneedle platform technology through 3D precision printing by altering their height, width, materials and sharpness. As\u00a0the result of a successful, long-standing relationship,\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/en\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-1-3.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-1-3.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-1-3.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-1-3.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-1-3.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2574,"url":"https:\/\/nish.wales\/en\/2025\/02\/26\/case-study-exploring-the-physical-and-mental-benefits-of-seat-warmers-on-vulnerable-adults\/","url_meta":{"origin":4224,"position":1},"title":"Case Study: Exploring the physical and mental benefits of seat warmers on vulnerable adults","author":"meganchick1","date":"26th February 2025","format":false,"excerpt":"Homeglow Products and Delta Wellbeing worked with Swansea University's Healthcare Technology Centre to help test a low-cost heated seat cover that keep vulnerable older adults warm at the touch of a button. Maintaining our internal temperature within a degree or two of 37 degrees is vital to a healthy body.\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/en\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/02\/Wordpress-11.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/02\/Wordpress-11.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/02\/Wordpress-11.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/02\/Wordpress-11.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/02\/Wordpress-11.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2535,"url":"https:\/\/nish.wales\/en\/2024\/10\/09\/case-study-innovating-community-care-with-delta-wellbeing\/","url_meta":{"origin":4224,"position":2},"title":"Case Study: Innovating Community Care with Delta Wellbeing","author":"meganchick1","date":"9th October 2024","format":false,"excerpt":"Delta Wellbeing\u2019s CONNECT and Blue Army services are enhancing home care, reducing hospital readmissions, and fostering innovation through collaboration with Network member the Healthcare Technology Centre (HTC). With over 11 million people aged 65 and over in England and Wales in 2021, and a projected 16% increase in Wales by\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/en\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/02\/Wordpress-6.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/02\/Wordpress-6.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/02\/Wordpress-6.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/02\/Wordpress-6.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2025\/02\/Wordpress-6.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":4160,"url":"https:\/\/nish.wales\/en\/2024\/03\/11\/case-study-developing-a-prototype-peripheral-intravenous-therapy-monitoring-device\/","url_meta":{"origin":4224,"position":3},"title":"Case Study: Developing a prototype peripheral intravenous therapy monitoring device","author":"meganchick1","date":"11th March 2024","format":false,"excerpt":"SenseIV is a multidisciplinary team developing wearable technology for healthcare to empower patients and staff in the use of peripheral intravenous therapy. The existing devices are fitted to patients of all types, from newborn to the elderly, to deliver intravenous fluids ranging from relatively harmless saline solutions through to the\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/en\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-3-2.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-3-2.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-3-2.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-3-2.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-3-2.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":4237,"url":"https:\/\/nish.wales\/en\/2024\/03\/13\/case-study-development-of-an-alternative-to-determine-the-bio-durability-of-man-made-fibres\/","url_meta":{"origin":4224,"position":4},"title":"Case Study: Development of an alternative to determine the bio-durability of man-made fibres","author":"meganchick1","date":"13th March 2024","format":false,"excerpt":"Knauf Insulation are a global, multi-million-pound insulation wool business\u00a0with 40 years of experience, who are\u00a0located\u00a0across Europe and the US. They\u00a0are\u00a0amongst the fastest growing\u00a0and most respected names in insulation worldwide, having an\u00a0interest in\u00a0helping\u00a0customers meet increasing demand for energy efficiency and sustainability in\u00a0buildings. Currently, there are growing concerns regarding the human health\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/en\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-13.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-13.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-13.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-13.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-13.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":4362,"url":"https:\/\/nish.wales\/en\/2026\/04\/15\/case-study-local-biohacking-clinic-advancing-recovery-performance-and-wellbeing\/","url_meta":{"origin":4224,"position":5},"title":"Case Study: Local Biohacking Clinic Advancing Recovery, Performance and Wellbeing","author":"meganchick1","date":"15th April 2026","format":false,"excerpt":"CryoCube is Wales\u2019 first dedicated biohacking clinic, delivering a range of holistic, cutting-edge therapies designed to support recovery, performance, and overall wellbeing. Their services include Hyperbaric Oxygen Therapy (HBOT), cryotherapy, red light therapy, halotherapy, sauna, and contrast therapy, which are all tailored to optimise physical and cognitive health. CryoCube was\u2026","rel":"","context":"In &quot;Case Study&quot;","block_context":{"text":"Case Study","link":"https:\/\/nish.wales\/en\/category\/case-study\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/04\/Wordpress.png?fit=1200%2C628&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/04\/Wordpress.png?fit=1200%2C628&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/04\/Wordpress.png?fit=1200%2C628&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/04\/Wordpress.png?fit=1200%2C628&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/04\/Wordpress.png?fit=1200%2C628&ssl=1&resize=1050%2C600 3x"},"classes":[]}],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/nish.wales\/wp-content\/uploads\/2026\/03\/Wordpress-6-1.png?fit=1200%2C628&ssl=1","_links":{"self":[{"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/posts\/4224","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/users\/190346150"}],"replies":[{"embeddable":true,"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/comments?post=4224"}],"version-history":[{"count":2,"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/posts\/4224\/revisions"}],"predecessor-version":[{"id":4227,"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/posts\/4224\/revisions\/4227"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/media\/4226"}],"wp:attachment":[{"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/media?parent=4224"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/categories?post=4224"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nish.wales\/en\/wp-json\/wp\/v2\/tags?post=4224"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}